{"id":12321,"date":"2018-03-03T18:13:49","date_gmt":"2018-03-03T18:13:49","guid":{"rendered":"https:\/\/netsteril.com\/?p=12321"},"modified":"2023-05-02T07:05:47","modified_gmt":"2023-05-02T07:05:47","slug":"airborne-disinfection-cleanrooms-vh2o2","status":"publish","type":"post","link":"https:\/\/netsteril.com\/en\/blog\/airborne-disinfection-cleanrooms-vh2o2\/","title":{"rendered":"Airborne disinfection of cleanrooms with VH2O2"},"content":{"rendered":"<div class=\"fusion-fullwidth fullwidth-box fusion-builder-row-1 fusion-flex-container nonhundred-percent-fullwidth non-hundred-percent-height-scrolling\" style=\"--awb-border-radius-top-left:0px;--awb-border-radius-top-right:0px;--awb-border-radius-bottom-right:0px;--awb-border-radius-bottom-left:0px;--awb-flex-wrap:wrap;\" ><div class=\"fusion-builder-row fusion-row fusion-flex-align-items-flex-start fusion-flex-content-wrap\" style=\"max-width:1414.4px;margin-left: calc(-4% \/ 2 );margin-right: calc(-4% \/ 2 );\"><div class=\"fusion-layout-column fusion_builder_column fusion-builder-column-0 fusion_builder_column_1_1 1_1 fusion-flex-column\" style=\"--awb-bg-size:cover;--awb-width-large:100%;--awb-margin-top-large:0px;--awb-spacing-right-large:1.92%;--awb-margin-bottom-large:0px;--awb-spacing-left-large:1.92%;--awb-width-medium:100%;--awb-spacing-right-medium:1.92%;--awb-spacing-left-medium:1.92%;--awb-width-small:100%;--awb-spacing-right-small:1.92%;--awb-spacing-left-small:1.92%;\"><div class=\"fusion-column-wrapper fusion-flex-justify-content-flex-start fusion-content-layout-column\"><div class=\"fusion-text fusion-text-1\"><p>The control of microbial burden on surfaces such as in GMP production areas, R&amp;D animal labs and hospitals is a daily challenge. Many rooms have high ceilings and are equipped with complex equipment, furniture, computers, etc. In practice it turns out that disinfection by wiping is a difficult task under these circumstances.<\/p>\n<p style=\"text-align: center;\"><img decoding=\"async\" class=\"lazyload alignnone size-full wp-image-12453\" src=\"https:\/\/netsteril.com\/wp-content\/uploads\/2023\/03\/courtesy-Enzler-Hygiene.jpg\" data-orig-src=\"https:\/\/netsteril.com\/wp-content\/uploads\/2023\/03\/courtesy-Enzler-Hygiene.jpg\" alt=\"Cleanroom disinfection.\" width=\"800\" height=\"533\" srcset=\"data:image\/svg+xml,%3Csvg%20xmlns%3D%27http%3A%2F%2Fwww.w3.org%2F2000%2Fsvg%27%20width%3D%27800%27%20height%3D%27533%27%20viewBox%3D%270%200%20800%20533%27%3E%3Crect%20width%3D%27800%27%20height%3D%27533%27%20fill-opacity%3D%220%22%2F%3E%3C%2Fsvg%3E\" data-srcset=\"https:\/\/netsteril.com\/wp-content\/uploads\/2023\/03\/courtesy-Enzler-Hygiene-200x133.jpg 200w, https:\/\/netsteril.com\/wp-content\/uploads\/2023\/03\/courtesy-Enzler-Hygiene-300x200.jpg 300w, https:\/\/netsteril.com\/wp-content\/uploads\/2023\/03\/courtesy-Enzler-Hygiene-400x267.jpg 400w, https:\/\/netsteril.com\/wp-content\/uploads\/2023\/03\/courtesy-Enzler-Hygiene-600x400.jpg 600w, https:\/\/netsteril.com\/wp-content\/uploads\/2023\/03\/courtesy-Enzler-Hygiene-768x512.jpg 768w, https:\/\/netsteril.com\/wp-content\/uploads\/2023\/03\/courtesy-Enzler-Hygiene.jpg 800w\" data-sizes=\"auto\" data-orig-sizes=\"(max-width: 800px) 100vw, 800px\" \/><br \/>\nPhoto: Courtesy of Enzler Hygiene AG<\/p>\n<p>Major drawbacks found consist of the following:<\/p>\n<ul>\n<li>difficult to access surfaces and areas: ceiling, areas behind and under furniture and fixtures<\/li>\n<li>contact time and pressure applied are highly dependent of personnel<\/li>\n<li>uniformity of application on all surfaces and reproducibility difficult to obtain and to prove<\/li>\n<li>laborious and time-consuming<\/li>\n<li>its validation is very intricate.<\/li>\n<\/ul>\n<p>Alternatively, airborne disinfection by means of nebulisation techniques allows overcoming many critical aspects of wiping in both procedure and validation. Moreover, the use of hydrogen peroxide (H<sub>2<\/sub>O<sub>2<\/sub>) with moderate concentration resolves remaining reservations as to toxicity, corrosion, and persistence. H<sub>2<\/sub>O<sub>2<\/sub>\u00a0decomposes into water (H<sub>2<\/sub>O) and oxygen (O<sub>2<\/sub>) over time and does not leave residues.<\/p>\n<div id=\"ez-toc-container\" class=\"ez-toc-v2_0_82_2 counter-hierarchy ez-toc-counter ez-toc-grey ez-toc-container-direction\">\n<div class=\"ez-toc-title-container\">\n<p class=\"ez-toc-title\" style=\"cursor:inherit\">\u00cdndice de contenidos<\/p>\n<span class=\"ez-toc-title-toggle\"><a href=\"#\" class=\"ez-toc-pull-right ez-toc-btn ez-toc-btn-xs ez-toc-btn-default ez-toc-toggle\" aria-label=\"Toggle Table of Content\"><span class=\"ez-toc-js-icon-con\"><span class=\"\"><span class=\"eztoc-hide\" style=\"display:none;\">Toggle<\/span><span class=\"ez-toc-icon-toggle-span\"><svg style=\"fill: #999;color:#999\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\" class=\"list-377408\" width=\"20px\" height=\"20px\" viewBox=\"0 0 24 24\" fill=\"none\"><path d=\"M6 6H4v2h2V6zm14 0H8v2h12V6zM4 11h2v2H4v-2zm16 0H8v2h12v-2zM4 16h2v2H4v-2zm16 0H8v2h12v-2z\" fill=\"currentColor\"><\/path><\/svg><svg style=\"fill: #999;color:#999\" class=\"arrow-unsorted-368013\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\" width=\"10px\" height=\"10px\" viewBox=\"0 0 24 24\" version=\"1.2\" baseProfile=\"tiny\"><path d=\"M18.2 9.3l-6.2-6.3-6.2 6.3c-.2.2-.3.4-.3.7s.1.5.3.7c.2.2.4.3.7.3h11c.3 0 .5-.1.7-.3.2-.2.3-.5.3-.7s-.1-.5-.3-.7zM5.8 14.7l6.2 6.3 6.2-6.3c.2-.2.3-.5.3-.7s-.1-.5-.3-.7c-.2-.2-.4-.3-.7-.3h-11c-.3 0-.5.1-.7.3-.2.2-.3.5-.3.7s.1.5.3.7z\"\/><\/svg><\/span><\/span><\/span><\/a><\/span><\/div>\n<nav><ul class='ez-toc-list ez-toc-list-level-1 ' ><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-1\" href=\"https:\/\/netsteril.com\/en\/blog\/airborne-disinfection-cleanrooms-vh2o2\/#Requirements_for_VH2O2_generation_equipment_and_the_biocide\" >Requirements for VH2O2\u00a0generation equipment and the biocide<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-2\" href=\"https:\/\/netsteril.com\/en\/blog\/airborne-disinfection-cleanrooms-vh2o2\/#Decontamination_process_technology\" >Decontamination process technology<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-3\" href=\"https:\/\/netsteril.com\/en\/blog\/airborne-disinfection-cleanrooms-vh2o2\/#Solidfog_solutions_for_cleanroom_decontamination\" >Solidfog solutions for cleanroom decontamination<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-4\" href=\"https:\/\/netsteril.com\/en\/blog\/airborne-disinfection-cleanrooms-vh2o2\/#DosyMist%C2%AE_unidad_movil_tipo_%E2%80%9Cplug-and-play%E2%80%9D_que_puede_cubrir_hasta_200_m3\" >DosyMist\u00ae unidad m\u00f3vil tipo &#8220;plug-and-play&#8221; que puede cubrir hasta 200 m3<\/a><ul class='ez-toc-list-level-3' ><li class='ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-5\" href=\"https:\/\/netsteril.com\/en\/blog\/airborne-disinfection-cleanrooms-vh2o2\/#DosyMistXL%C2%AE_mobile_%E2%80%9Cplug-and-play%E2%80%9D_unit_that_can_cover_up_to_750_m3\" >DosyMistXL\u00ae mobile \u201cplug-and-play\u201d unit that can cover up to 750 m3<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-6\" href=\"https:\/\/netsteril.com\/en\/blog\/airborne-disinfection-cleanrooms-vh2o2\/#Sistema_DosyMistDS%C2%AE_deployed_system_for_specific_applications_like_a_pass-box_or_Material_Air_Lock_MAL\" >Sistema DosyMistDS\u00ae deployed system for specific applications like a pass-box or Material Air Lock (MAL)<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-7\" href=\"https:\/\/netsteril.com\/en\/blog\/airborne-disinfection-cleanrooms-vh2o2\/#DosyMistCS%C2%AE_fixed_centralised_system_by_means_of_spray_heads_installed_in_rooms_connected_to_a_central_unit_installed_in_a_technical_area\" >DosyMistCS\u00ae fixed centralised system by means of spray heads installed in rooms connected to a central unit installed in a technical area.<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-8\" href=\"https:\/\/netsteril.com\/en\/blog\/airborne-disinfection-cleanrooms-vh2o2\/#Sistema_catalitico_NeutraMist%C2%AE_in_order_to_decrease_the_aeration_phase_which_is_typically_the_longer_of_the_cycle\" >Sistema catal\u00edtico NeutraMist\u00ae in order to decrease the aeration phase, which is typically the longer of the cycle.<\/a><\/li><\/ul><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-9\" href=\"https:\/\/netsteril.com\/en\/blog\/airborne-disinfection-cleanrooms-vh2o2\/#Cycle_development_and_Validation\" >Cycle development and Validation<\/a><\/li><\/ul><\/nav><\/div>\n<h2 class=\"fusion-responsive-typography-calculated\" data-fontsize=\"19\" data-lineheight=\"28.5px\"><span class=\"ez-toc-section\" id=\"Requirements_for_VH2O2_generation_equipment_and_the_biocide\"><\/span><strong>Requirements for VH<sub>2<\/sub>O<sub>2<\/sub>\u00a0generation equipment and the biocide<\/strong><span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p>Airborne disinfection is carried out with two elements: the biocide solution and the generator to produce its vaporisation. Solidfog generators are based on micro-nebulisation technology, consisting in the atomisation of a liquid when submitted to high pressure, which converts into vapour until saturation under normal environmental conditions. The composition, design and combination of both elements have to proof its efficacy for a specific application such as the decontamination of a cleanroom.<\/p>\n<p>The main requirements to approach an airborne disinfection are:<\/p>\n<ul>\n<li>flexibility: applicable for small and large rooms\/volumes (scalable)<\/li>\n<li>minimal requirements as to environmental conditions (temperature, humidity)<\/li>\n<li>quick install: either mobile or fix-installed equipment<\/li>\n<li>safe use for personnel: non-hazardous, low toxicity<\/li>\n<li>non-corrosive chemical, non-persistent<\/li>\n<li>ease of clearing after fumigation, fast operability<\/li>\n<li>no residues, harmless by-products from decomposition, no need for neutralization<\/li>\n<li>broad inactivation spectrum (bacteria, virus, yeast, molds)<\/li>\n<li>high inactivation rate (kill rate) and efficiency<\/li>\n<li>simple and reliable qualification method for efficiency<\/li>\n<li>validated process, fast and robust<\/li>\n<li>can be used while working in adjacent rooms (providing AHU allow for it).<\/li>\n<\/ul>\n<h2 class=\"fusion-responsive-typography-calculated\" data-fontsize=\"19\" data-lineheight=\"28.5px\"><span class=\"ez-toc-section\" id=\"Decontamination_process_technology\"><\/span><span id=\"Decontamination_process_technology\" class=\"ez-toc-section\"><\/span><strong>Decontamination process technology<\/strong><span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p>All these requirements are properly considered and technically solved by Solidfog.<\/p>\n<p>Solidfog has more than 10 years\u2019 experience in providing H<sub>2<\/sub>O<sub>2\u00a0<\/sub>airborne decontamination systems for the pharmaceutical industry with a successful track record behind. Our nebulisation technology ensures a uniform and reproducible distribution of the H<sub>2<\/sub>O<sub>2<\/sub>\u00a0throughout the whole room. Thanks to the design of the spray nozzle, the precision of the biocide priming pump and control over the air pressure provided by our design, we ensure a robust and consistent aerosol supply. Studies conducted by the company with laser diffraction particle analysis have demonstrated a median droplet size of 10 \u00b5m. This size is ideal for a quick dispersion and an effective vaporisation till saturation point.<\/p>\n<p><img decoding=\"async\" class=\"lazyload wp-image-11117 size-full alignleft\" src=\"data:image\/svg+xml,%3Csvg%20xmlns%3D%27http%3A%2F%2Fwww.w3.org%2F2000%2Fsvg%27%20width%3D%27400%27%20height%3D%27300%27%20viewBox%3D%270%200%20400%20300%27%3E%3Crect%20width%3D%27400%27%20height%3D%27300%27%20fill-opacity%3D%220%22%2F%3E%3C%2Fsvg%3E\" data-orig-src=\"https:\/\/netsteril.com\/wp-content\/uploads\/2023\/03\/solidfog-spray-nozzle.jpg\" alt=\"Solidfog spray nozzle.\" width=\"400\" height=\"300\" \/><\/p>\n<p>In principle, a decontamination process carried out in normal environmental conditions can be rendered without the need of preconditioning phase regarding temperature and humidity. However, these are factors to be considered during cycle development and validation. \u00a0Studies conducted by an important pharmaceutical company showed that RH conditions between 40-70% and temperatures between 17-27\u00b0C can be properly validated to 6-log reduction by adjusting H<sub>2<\/sub>O<sub>2<\/sub>\u00a0initial liquid concentration. The cycle development strategy should consider the worst case situation and try to fix the concentration of H<sub>2<\/sub>O<sub>2<\/sub>\u00a0for simplifying validation. Solidfog typically recommends a dilution with 12%, which renders the best compromise between sporicidal efficiency and compatibility with materials used in these areas. For such concentration, the ideal starting conditions are 40% RH and 20\u00b0C but other starting conditions can be challenged as the results are also influenced by other factors like the overall volume, the related surfaces to be treated and the geometry of the area. Microbiologist have reported in some cases for killing certain virus or bacteria is more convenient a higher humidity, providing a higher level of micro-condensation. In conclusion, there\u2019s not a fixed rule to be followed and only after a case analysis and a job of cycle development (cycle trials), it will be possible to determine the cycle parameters to be validated.<\/p>\n<p><img decoding=\"async\" class=\"lazyload size-full wp-image-12450 aligncenter\" src=\"https:\/\/netsteril.com\/wp-content\/uploads\/2023\/03\/biodecontamination-graph.jpg\" data-orig-src=\"https:\/\/netsteril.com\/wp-content\/uploads\/2023\/03\/biodecontamination-graph.jpg\" alt=\"Graph of cycle parameters.\" width=\"911\" height=\"675\" srcset=\"data:image\/svg+xml,%3Csvg%20xmlns%3D%27http%3A%2F%2Fwww.w3.org%2F2000%2Fsvg%27%20width%3D%27911%27%20height%3D%27675%27%20viewBox%3D%270%200%20911%20675%27%3E%3Crect%20width%3D%27911%27%20height%3D%27675%27%20fill-opacity%3D%220%22%2F%3E%3C%2Fsvg%3E\" data-srcset=\"https:\/\/netsteril.com\/wp-content\/uploads\/2023\/03\/biodecontamination-graph-200x148.jpg 200w, https:\/\/netsteril.com\/wp-content\/uploads\/2023\/03\/biodecontamination-graph-300x222.jpg 300w, https:\/\/netsteril.com\/wp-content\/uploads\/2023\/03\/biodecontamination-graph-400x296.jpg 400w, https:\/\/netsteril.com\/wp-content\/uploads\/2023\/03\/biodecontamination-graph-600x445.jpg 600w, https:\/\/netsteril.com\/wp-content\/uploads\/2023\/03\/biodecontamination-graph-768x569.jpg 768w, https:\/\/netsteril.com\/wp-content\/uploads\/2023\/03\/biodecontamination-graph-800x593.jpg 800w, https:\/\/netsteril.com\/wp-content\/uploads\/2023\/03\/biodecontamination-graph.jpg 911w\" data-sizes=\"auto\" data-orig-sizes=\"(max-width: 911px) 100vw, 911px\" \/><\/p>\n<p>Solidfog has the process experience and know-how to offer this support to the customer. According to specific limitations in terms of environmental and architecture conditions, Solidfog shall recommend the number and position of spray nozzles, the orientation within the room, the pressure into the spray nozzle, the quantity and concentration of disinfectant, the length of exposure time, etc.<\/p>\n<h2 class=\"fusion-responsive-typography-calculated\" data-fontsize=\"19\" data-lineheight=\"28.5px\"><span class=\"ez-toc-section\" id=\"Solidfog_solutions_for_cleanroom_decontamination\"><\/span><strong>Solidfog solutions for cleanroom decontamination<\/strong><span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p>Solidfog has developed a range of equipment in order to better solve different cases and customer needs. These are:<\/p>\n<h2><span class=\"ez-toc-section\" id=\"DosyMist%C2%AE_unidad_movil_tipo_%E2%80%9Cplug-and-play%E2%80%9D_que_puede_cubrir_hasta_200_m3\"><\/span><strong style=\"font-size: 16px;\">DosyMist<sup>\u00ae<\/sup> <\/strong><span style=\"font-size: 16px;\">unidad m\u00f3vil tipo &#8220;plug-and-play&#8221; que puede cubrir hasta 200 m<sup>3<\/sup><\/span><span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p><img decoding=\"async\" class=\"lazyload size-full wp-image-12438 aligncenter\" src=\"https:\/\/netsteril.com\/wp-content\/uploads\/2023\/03\/solidfog-dosymist-unit.jpg\" data-orig-src=\"https:\/\/netsteril.com\/wp-content\/uploads\/2023\/03\/solidfog-dosymist-unit.jpg\" alt=\"DosyMist mobile \u201cplug-and-play\u201dunit can cover up to 200 m3.\" width=\"480\" height=\"640\" srcset=\"data:image\/svg+xml,%3Csvg%20xmlns%3D%27http%3A%2F%2Fwww.w3.org%2F2000%2Fsvg%27%20width%3D%27480%27%20height%3D%27640%27%20viewBox%3D%270%200%20480%20640%27%3E%3Crect%20width%3D%27480%27%20height%3D%27640%27%20fill-opacity%3D%220%22%2F%3E%3C%2Fsvg%3E\" data-srcset=\"https:\/\/netsteril.com\/wp-content\/uploads\/2023\/03\/solidfog-dosymist-unit-200x267.jpg 200w, https:\/\/netsteril.com\/wp-content\/uploads\/2023\/03\/solidfog-dosymist-unit-225x300.jpg 225w, https:\/\/netsteril.com\/wp-content\/uploads\/2023\/03\/solidfog-dosymist-unit-400x533.jpg 400w, https:\/\/netsteril.com\/wp-content\/uploads\/2023\/03\/solidfog-dosymist-unit.jpg 480w\" data-sizes=\"auto\" data-orig-sizes=\"(max-width: 480px) 100vw, 480px\" \/><\/p>\n<h3><span class=\"ez-toc-section\" id=\"DosyMistXL%C2%AE_mobile_%E2%80%9Cplug-and-play%E2%80%9D_unit_that_can_cover_up_to_750_m3\"><\/span><strong>DosyMist<sup>XL\u00ae<\/sup><\/strong> mobile \u201cplug-and-play\u201d unit that can cover up to 750 m<sup>3<\/sup><span class=\"ez-toc-section-end\"><\/span><\/h3>\n<p><img decoding=\"async\" class=\"lazyload size-full wp-image-12441 aligncenter\" src=\"https:\/\/netsteril.com\/wp-content\/uploads\/2023\/03\/solidfog-dosymist-XL-unit.jpg\" data-orig-src=\"https:\/\/netsteril.com\/wp-content\/uploads\/2023\/03\/solidfog-dosymist-XL-unit.jpg\" alt=\"DosyMist XL mobile &quot;plug-and-play&quot; unit\" width=\"800\" height=\"550\" srcset=\"data:image\/svg+xml,%3Csvg%20xmlns%3D%27http%3A%2F%2Fwww.w3.org%2F2000%2Fsvg%27%20width%3D%27800%27%20height%3D%27550%27%20viewBox%3D%270%200%20800%20550%27%3E%3Crect%20width%3D%27800%27%20height%3D%27550%27%20fill-opacity%3D%220%22%2F%3E%3C%2Fsvg%3E\" data-srcset=\"https:\/\/netsteril.com\/wp-content\/uploads\/2023\/03\/solidfog-dosymist-XL-unit-200x138.jpg 200w, https:\/\/netsteril.com\/wp-content\/uploads\/2023\/03\/solidfog-dosymist-XL-unit-300x206.jpg 300w, https:\/\/netsteril.com\/wp-content\/uploads\/2023\/03\/solidfog-dosymist-XL-unit-400x275.jpg 400w, https:\/\/netsteril.com\/wp-content\/uploads\/2023\/03\/solidfog-dosymist-XL-unit-600x413.jpg 600w, https:\/\/netsteril.com\/wp-content\/uploads\/2023\/03\/solidfog-dosymist-XL-unit-768x528.jpg 768w, https:\/\/netsteril.com\/wp-content\/uploads\/2023\/03\/solidfog-dosymist-XL-unit.jpg 800w\" data-sizes=\"auto\" data-orig-sizes=\"(max-width: 800px) 100vw, 800px\" \/><\/p>\n<h3><span class=\"ez-toc-section\" id=\"Sistema_DosyMistDS%C2%AE_deployed_system_for_specific_applications_like_a_pass-box_or_Material_Air_Lock_MAL\"><\/span><strong>Sistema DosyMist<sup>DS\u00ae<\/sup><\/strong> deployed system for specific applications like a pass-box or Material Air Lock (MAL)<span class=\"ez-toc-section-end\"><\/span><\/h3>\n<h3><span class=\"ez-toc-section\" id=\"DosyMistCS%C2%AE_fixed_centralised_system_by_means_of_spray_heads_installed_in_rooms_connected_to_a_central_unit_installed_in_a_technical_area\"><\/span><strong>DosyMist<sup>CS\u00ae<\/sup><\/strong> fixed centralised system by means of spray heads installed in rooms connected to a central unit installed in a technical area.<span class=\"ez-toc-section-end\"><\/span><\/h3>\n<p><img decoding=\"async\" class=\"lazyload size-full wp-image-12432 aligncenter\" src=\"https:\/\/netsteril.com\/wp-content\/uploads\/2023\/03\/spray-nozzle.jpg\" data-orig-src=\"https:\/\/netsteril.com\/wp-content\/uploads\/2023\/03\/spray-nozzle.jpg\" alt=\"Spray nozzle installed in a cleanroom.\" width=\"801\" height=\"541\" srcset=\"data:image\/svg+xml,%3Csvg%20xmlns%3D%27http%3A%2F%2Fwww.w3.org%2F2000%2Fsvg%27%20width%3D%27801%27%20height%3D%27541%27%20viewBox%3D%270%200%20801%20541%27%3E%3Crect%20width%3D%27801%27%20height%3D%27541%27%20fill-opacity%3D%220%22%2F%3E%3C%2Fsvg%3E\" data-srcset=\"https:\/\/netsteril.com\/wp-content\/uploads\/2023\/03\/spray-nozzle-200x135.jpg 200w, https:\/\/netsteril.com\/wp-content\/uploads\/2023\/03\/spray-nozzle-300x203.jpg 300w, https:\/\/netsteril.com\/wp-content\/uploads\/2023\/03\/spray-nozzle-400x270.jpg 400w, https:\/\/netsteril.com\/wp-content\/uploads\/2023\/03\/spray-nozzle-600x405.jpg 600w, https:\/\/netsteril.com\/wp-content\/uploads\/2023\/03\/spray-nozzle-768x519.jpg 768w, https:\/\/netsteril.com\/wp-content\/uploads\/2023\/03\/spray-nozzle.jpg 801w\" data-sizes=\"auto\" data-orig-sizes=\"(max-width: 801px) 100vw, 801px\" \/><\/p>\n<h3 style=\"text-align: left;\"><span class=\"ez-toc-section\" id=\"Sistema_catalitico_NeutraMist%C2%AE_in_order_to_decrease_the_aeration_phase_which_is_typically_the_longer_of_the_cycle\"><\/span><strong>Sistema catal\u00edtico NeutraMist<sup>\u00ae <\/sup><\/strong>in order to decrease the aeration phase, which is typically the longer of the cycle.<span class=\"ez-toc-section-end\"><\/span><\/h3>\n<p><img decoding=\"async\" class=\"lazyload wp-image-12447 aligncenter\" src=\"https:\/\/netsteril.com\/wp-content\/uploads\/2023\/03\/solidfog-neutramist-equipment.jpg\" data-orig-src=\"https:\/\/netsteril.com\/wp-content\/uploads\/2023\/03\/solidfog-neutramist-equipment.jpg\" alt=\"Solidfog NeutraMist catalytic system.\" width=\"402\" height=\"716\" srcset=\"data:image\/svg+xml,%3Csvg%20xmlns%3D%27http%3A%2F%2Fwww.w3.org%2F2000%2Fsvg%27%20width%3D%27402%27%20height%3D%27716%27%20viewBox%3D%270%200%20402%20716%27%3E%3Crect%20width%3D%27402%27%20height%3D%27716%27%20fill-opacity%3D%220%22%2F%3E%3C%2Fsvg%3E\" data-srcset=\"https:\/\/netsteril.com\/wp-content\/uploads\/2023\/03\/solidfog-neutramist-equipment-169x300.jpg 169w, https:\/\/netsteril.com\/wp-content\/uploads\/2023\/03\/solidfog-neutramist-equipment-200x356.jpg 200w, https:\/\/netsteril.com\/wp-content\/uploads\/2023\/03\/solidfog-neutramist-equipment-400x712.jpg 400w, https:\/\/netsteril.com\/wp-content\/uploads\/2023\/03\/solidfog-neutramist-equipment-575x1024.jpg 575w, https:\/\/netsteril.com\/wp-content\/uploads\/2023\/03\/solidfog-neutramist-equipment-600x1068.jpg 600w, https:\/\/netsteril.com\/wp-content\/uploads\/2023\/03\/solidfog-neutramist-equipment.jpg 768w\" data-sizes=\"auto\" data-orig-sizes=\"(max-width: 402px) 100vw, 402px\" \/><\/p>\n<p>The approach towards cleanroom disinfection starts with the collection of different data:<\/p>\n<ul>\n<li>Cleanroom area architecture (layout) with identification of equipment and furniture<\/li>\n<li>Overall volume<\/li>\n<li>Defining areas with common AHU that need to be decontaminated together<\/li>\n<li>HVAC system design and performance (Air Changes per Hour)<\/li>\n<li>Frequency of decontaminations per area and expected lead times<\/li>\n<li>Expected log-reduction<\/li>\n<li>Confirmation that cleanroom panels (especially painting) are prepared to be processed with H2O2. This should be confirmed by the supplier of the panels.<\/li>\n<li>Information about the typical environmental conditions (Relative Humidity and Temperature) and peak levels along the different year\u2019s season, as they influence the performance of the decontamination cycle.<\/li>\n<li>Information about the cleaning or disinfecting procedures performed before the decontamination. Traces over the surfaces could lead to chemical reactions and produce corrosion problems.<\/li>\n<li>Information about specific hots or cold spots or surfaces (e.g. autoclaves, freeze-dryers, piping, etc.) that could have an adverse effect over H2O2 decontamination or produce too much condensation.<\/li>\n<\/ul>\n<p>Based on this information, we shall come back with a proposal as a first approach including:<\/p>\n<ol>\n<li>Position and number of units as well as the direction of the spray heads according to layout and internal elements (machinery, furniture, etc.)<\/li>\n<li>Quantity of biocide based on a fixed concentration of H<sub>2<\/sub>O<sub>2<\/sub>.<\/li>\n<li>Estimation of cycle phase lead times (conditioning and contact phase) as per targeted log reduction. However, these values will always be an estimate. Lead times are highly dependent on the adsorption capacity of materials remaining in the room (i.e. filters), the concentration of H2O2, the architecture and the performance of air renewal provided by the HVAC system, etc.<\/li>\n<\/ol>\n<h2 class=\"fusion-responsive-typography-calculated\" data-fontsize=\"19\" data-lineheight=\"28.5px\"><span class=\"ez-toc-section\" id=\"Cycle_development_and_Validation\"><\/span><strong>Cycle development and Validation<\/strong><span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p>The definition of cycle parameter values (quantity of biocide, injection rates, pressure, etc.) of the equipment for a certain application (Room, MAL, etc.) will be based on Solidfog\u2019s experience. As said before, this must be defined on a case by case basis and according to specific environmental conditions and the other above mentioned information. Furthermore, these values render a cycle that must be tested and duly validated. The purpose of cycle development is to find a good compromise between effective and assured decontamination, consumption of biocide and cycle lead times (especially in regards of exposure and aeration), challenging the system on worst case conditions. Typically, these tests are initially performed using chemical indicators in first instance. Right after making some adjustments, you can proceed with\u00a0<a href=\"https:\/\/netsteril.com\/en\/products\/vh2o2-enzimatic-indicators-protak\/\">enzyme indicators<\/a>\u00a0and\/or tri-scale biological indicators to know the level of log-reduction.<\/p>\n<p><img decoding=\"async\" class=\"lazyload size-full wp-image-12444 aligncenter\" src=\"https:\/\/netsteril.com\/wp-content\/uploads\/2023\/03\/decontamination-cycle-graph.jpg\" data-orig-src=\"https:\/\/netsteril.com\/wp-content\/uploads\/2023\/03\/decontamination-cycle-graph.jpg\" alt=\"Graph of a decontamination cycle with VH2O2 by nebulisation.\" width=\"800\" height=\"397\" srcset=\"data:image\/svg+xml,%3Csvg%20xmlns%3D%27http%3A%2F%2Fwww.w3.org%2F2000%2Fsvg%27%20width%3D%27800%27%20height%3D%27397%27%20viewBox%3D%270%200%20800%20397%27%3E%3Crect%20width%3D%27800%27%20height%3D%27397%27%20fill-opacity%3D%220%22%2F%3E%3C%2Fsvg%3E\" data-srcset=\"https:\/\/netsteril.com\/wp-content\/uploads\/2023\/03\/decontamination-cycle-graph-200x99.jpg 200w, https:\/\/netsteril.com\/wp-content\/uploads\/2023\/03\/decontamination-cycle-graph-300x149.jpg 300w, https:\/\/netsteril.com\/wp-content\/uploads\/2023\/03\/decontamination-cycle-graph-400x199.jpg 400w, https:\/\/netsteril.com\/wp-content\/uploads\/2023\/03\/decontamination-cycle-graph-600x298.jpg 600w, https:\/\/netsteril.com\/wp-content\/uploads\/2023\/03\/decontamination-cycle-graph-768x381.jpg 768w, https:\/\/netsteril.com\/wp-content\/uploads\/2023\/03\/decontamination-cycle-graph.jpg 800w\" data-sizes=\"auto\" data-orig-sizes=\"(max-width: 800px) 100vw, 800px\" \/><\/p>\n<p><strong>Figure:\u00a0<\/strong>The profile of a VH<sub>2<\/sub>O<sub>2<\/sub>\u00a0biodecontamination cycle by fogging. The conditioning phase does not require any type of dehumidification. The contact phase begins when the saturation point is reached and therefore the appropriate micro-condensation level occurs. The aeration phase consists of renewing the air and the speed depends on the air extraction system of the area or room.<\/p>\n<p>Validation is the last step and it should be carried out only after cycle development has been successfully finished. In case the BIs give strange results, it is 3 units per position as proactive measure to ensure they are not due to wrong handling or the use of rogue biological indicators. Some of the samples must be placed at the most difficult access points to ensure that there is no contamination risk. Once the results show no growth, the parameters of the cycle are established in the equipment in order to ensure reproducibility. These are: the quantity of biocide, the pressure of injection and the flow rate. Position\u00a0and direction of the spray nozzles have to be observed too.\u00a0So in order to ensure the reproducibility of the cycle,\u00a0it is paramount that the equipment provides internal monitoring and recording systems, as it is in the case of Solidfog.<\/p>\n<\/div><\/div><\/div><\/div><\/div>\n\n\n<div class=\"kk-star-ratings kksr-auto kksr-align-left kksr-valign-bottom\"\n    data-payload='{&quot;align&quot;:&quot;left&quot;,&quot;id&quot;:&quot;12321&quot;,&quot;slug&quot;:&quot;default&quot;,&quot;valign&quot;:&quot;bottom&quot;,&quot;ignore&quot;:&quot;&quot;,&quot;reference&quot;:&quot;auto&quot;,&quot;class&quot;:&quot;&quot;,&quot;count&quot;:&quot;0&quot;,&quot;legendonly&quot;:&quot;&quot;,&quot;readonly&quot;:&quot;&quot;,&quot;score&quot;:&quot;0&quot;,&quot;starsonly&quot;:&quot;&quot;,&quot;best&quot;:&quot;5&quot;,&quot;gap&quot;:&quot;5&quot;,&quot;greet&quot;:&quot;post&quot;,&quot;legend&quot;:&quot;0\\\/5 - (0 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