{"id":12278,"date":"2023-01-23T11:29:50","date_gmt":"2023-01-23T11:29:50","guid":{"rendered":"https:\/\/netsteril.com\/?p=12278"},"modified":"2026-02-12T16:41:26","modified_gmt":"2026-02-12T16:41:26","slug":"gmp-washing-machines-cop-equipment","status":"publish","type":"post","link":"https:\/\/netsteril.com\/en\/blog\/gmp-washing-machines-cop-equipment\/","title":{"rendered":"GMP washing machines: COP equipment"},"content":{"rendered":"<div class=\"fusion-fullwidth fullwidth-box fusion-builder-row-1 fusion-flex-container nonhundred-percent-fullwidth non-hundred-percent-height-scrolling\" style=\"--awb-border-radius-top-left:0px;--awb-border-radius-top-right:0px;--awb-border-radius-bottom-right:0px;--awb-border-radius-bottom-left:0px;--awb-flex-wrap:wrap;\" ><div class=\"fusion-builder-row fusion-row fusion-flex-align-items-flex-start fusion-flex-content-wrap\" style=\"max-width:1414.4px;margin-left: calc(-4% \/ 2 );margin-right: calc(-4% \/ 2 );\"><div class=\"fusion-layout-column fusion_builder_column fusion-builder-column-0 fusion_builder_column_1_1 1_1 fusion-flex-column\" style=\"--awb-bg-size:cover;--awb-width-large:100%;--awb-margin-top-large:0px;--awb-spacing-right-large:1.92%;--awb-margin-bottom-large:0px;--awb-spacing-left-large:1.92%;--awb-width-medium:100%;--awb-spacing-right-medium:1.92%;--awb-spacing-left-medium:1.92%;--awb-width-small:100%;--awb-spacing-right-small:1.92%;--awb-spacing-left-small:1.92%;\"><div class=\"fusion-column-wrapper fusion-flex-justify-content-flex-start fusion-content-layout-column\"><div class=\"fusion-text fusion-text-1\"><div id=\"ez-toc-container\" class=\"ez-toc-v2_0_84 counter-hierarchy ez-toc-counter ez-toc-grey ez-toc-container-direction\">\n<div class=\"ez-toc-title-container\">\n<p class=\"ez-toc-title\" style=\"cursor:inherit\">\u00cdndice de contenidos<\/p>\n<span class=\"ez-toc-title-toggle\"><a href=\"#\" class=\"ez-toc-pull-right ez-toc-btn ez-toc-btn-xs ez-toc-btn-default ez-toc-toggle\" aria-label=\"Toggle Table of Content\"><span class=\"ez-toc-js-icon-con\"><span class=\"\"><span class=\"eztoc-hide\" style=\"display:none;\">Toggle<\/span><span class=\"ez-toc-icon-toggle-span\"><svg style=\"fill: #999;color:#999\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\" class=\"list-377408\" width=\"20px\" height=\"20px\" viewBox=\"0 0 24 24\" fill=\"none\"><path d=\"M6 6H4v2h2V6zm14 0H8v2h12V6zM4 11h2v2H4v-2zm16 0H8v2h12v-2zM4 16h2v2H4v-2zm16 0H8v2h12v-2z\" fill=\"currentColor\"><\/path><\/svg><svg style=\"fill: #999;color:#999\" class=\"arrow-unsorted-368013\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\" width=\"10px\" height=\"10px\" viewBox=\"0 0 24 24\" version=\"1.2\" baseProfile=\"tiny\"><path d=\"M18.2 9.3l-6.2-6.3-6.2 6.3c-.2.2-.3.4-.3.7s.1.5.3.7c.2.2.4.3.7.3h11c.3 0 .5-.1.7-.3.2-.2.3-.5.3-.7s-.1-.5-.3-.7zM5.8 14.7l6.2 6.3 6.2-6.3c.2-.2.3-.5.3-.7s-.1-.5-.3-.7c-.2-.2-.4-.3-.7-.3h-11c-.3 0-.5.1-.7.3-.2.2-.3.5-.3.7s.1.5.3.7z\"\/><\/svg><\/span><\/span><\/span><\/a><\/span><\/div>\n<nav><ul class='ez-toc-list ez-toc-list-level-1 ' ><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-1\" href=\"https:\/\/netsteril.com\/en\/blog\/gmp-washing-machines-cop-equipment\/#What_is_a_GMP_washing_machine\" >What is a GMP washing machine?<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-2\" href=\"https:\/\/netsteril.com\/en\/blog\/gmp-washing-machines-cop-equipment\/#Know_the_benefits_and_return_on_investment\" >Know the benefits and return on investment<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-3\" href=\"https:\/\/netsteril.com\/en\/blog\/gmp-washing-machines-cop-equipment\/#The_advantages_of_automation\" >The advantages of automation<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-4\" href=\"https:\/\/netsteril.com\/en\/blog\/gmp-washing-machines-cop-equipment\/#Project_Considerations\" >Project Considerations<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-5\" href=\"https:\/\/netsteril.com\/en\/blog\/gmp-washing-machines-cop-equipment\/#Comparative_table_between_manual_vs_automatic_cleaning\" >Comparative table between manual vs automatic cleaning<\/a><\/li><\/ul><\/nav><\/div>\n<h2 class=\"fusion-responsive-typography-calculated\" data-fontsize=\"19\" data-lineheight=\"28.5px\"><span class=\"ez-toc-section\" id=\"What_is_a_GMP_washing_machine\"><\/span><span lang=\"EN-GB\">What is a GMP washing machine?<\/span><span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p>In pharmaceutical industry, automatic cleaning is usually associated with the acronym CIP (Cleaning In Place) and certainly, CIP systems are very common in applications such as tanks, reactors and others. On the other hand, the acronym COP (Cleaning Out of Place) is not so much well known.\u00a0<strong>GMP washing machines are the genuine COP equipment<\/strong>, but in our country these devices are not as widespread as one would expect. Why there is not enough effort being made in COP automation?<\/p>\n<p>There may be several reasons that would explain this situation. I suspect that one is a certain lack of knowledge about the state-of-the-art technology. When you think of a washing machine for contact parts, many times we assimilate it to what a dishwasher can do. E.g. small parts such as tablet punches, dosing pumps and nozzles, and above all, glass containers and instruments. There is also some belief that cleaning of parts with complex shapes requires the flexibility and dedication of manual washing and that it is very difficult to automate. The truth is that GMP washers are much more complex than a professional dishwasher and they offer custom made solutions for multiple parts in the same cycle, from containers of all types, sizes and shapes to hoses, pieces and utensils.<\/p>\n<p>Another aspect that slows the investment is the price issue. These are ancillary equipment, non-directly productive and when investments are planned, they are always a second priority. Sometimes, when they are considered, they are wrongly compared with other product categories like laboratory washing machines and budgets are not properly managed.<\/p>\n<p>In order to properly approach the matter of cleaning automation in pharma, we should understand the advantages and benefits that the GMP washers are offering.<\/p>\n<h2><span class=\"ez-toc-section\" id=\"Know_the_benefits_and_return_on_investment\"><\/span><span lang=\"EN-GB\">Know the benefits and return on investment<\/span><span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p>Since it is not production equipment but ancillary, we should assess the savings it could provide in terms of operating costs. A short list of them could be:<\/p>\n<h5 style=\"text-align: right;\"><img decoding=\"async\" class=\"lazyload alignright\" src=\"data:image\/svg+xml,%3Csvg%20xmlns%3D%27http%3A%2F%2Fwww.w3.org%2F2000%2Fsvg%27%20width%3D%27635%27%20height%3D%27452%27%20viewBox%3D%270%200%20635%20452%27%3E%3Crect%20width%3D%27635%27%20height%3D%27452%27%20fill-opacity%3D%220%22%2F%3E%3C%2Fsvg%3E\" data-orig-src=\"\/wp-content\/uploads\/2023\/03\/gmp-washing-machine-hamo.jpg\" alt=\"View of a Hamo Cleaning Technology GMP washing machine.\" width=\"635\" height=\"452\" \/><\/h5>\n<ul>\n<li>Savings in hours of personnel dedicated to manual cleaning. Release from tedious, repetitive and little value tasks.<\/li>\n<li>Savings in training and qualification of personnel. Elimination of the rotation problem.<\/li>\n<li>Saving for lowering the frequency of inspections by supervisory personnel.<\/li>\n<li>Savings in the use of consumables: detergents, tools, clothing and EPIs of operators (about 1\/3 or 1\/4 of the costs in manual).<\/li>\n<li>Savings in energy and water consumption (PW and WFI)<\/li>\n<li>Increase of productivity due to reduction of down time due to cleaning of parts.<\/li>\n<\/ul>\n<h2><span class=\"ez-toc-section\" id=\"The_advantages_of_automation\"><\/span>The advantages of automation<span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p>Investment in GMP washers provides other improvements, especially related to quality assurance and labour safety. These are:<\/p>\n<ul>\n<li><strong>Reliability.\u00a0<\/strong>In a manual process, after training, we must rely on the execution by the operator; its discipline and rigor in carrying out the task according to the validated protocol. These two qualities cannot always be properly monitored. Instead, automatic equipment works with recipes; a set of parameters that make up a cycle, with a continuous monitoring of critical parameters which are fully reproducible and, therefore, validatable.<\/li>\n<li><strong>Flexibility.\u00a0<\/strong>Contrary to what people believe, GMP washing machines have great flexibility in terms of cleaning parts or design of pieces and can process a wide variety of materials in the same cycle. From containers to hoses, connections and parts of very diverse nature: steels, plastics, resins, rubber and others. Production can be organized straight forward in batches and adjusted to the process.<\/li>\n<li><strong>Efficiency.\u00a0<\/strong>As mentioned, automation allows you to optimize consumption; both due to the amount of water, detergents and energy needed and due to reduced cycle times. In addition, it allows to ensure the proper drying of the load, an important issue since water residues over the cleaned components can favour microbial growth.<\/li>\n<li><strong>Safety and ergonomic.\u00a0<\/strong>Working with washing machines allows limiting the risks arising from the manual cleaning of contaminated parts. Operator exposure is eliminated according to what types of chemicals. Cleaning can also pose risks due to the use of hot water, detergents or even steam.<\/li>\n<li><strong>Compliance.\u00a0<\/strong>GMPs advocate that everything that is automatable should be automated. The reason is very simple; the ability of a machine to always reproduce the same and in the same way is always superior to that of a person.<\/li>\n<\/ul>\n<h2 class=\"fusion-responsive-typography-calculated\" data-fontsize=\"19\" data-lineheight=\"28.5px\"><span class=\"ez-toc-section\" id=\"Project_Considerations\"><\/span>Project Considerations<span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p>In order to prepare the investment, and to ensure a correct budget allocation, it would be necessary to prepare the URS in which the different stakeholders should participate; engineering, maintenance, production and quality control. By incorporating all these perspectives, we assure that the project will be developed properly, without last minute surprises.<\/p>\n<p>In general, there are three major issues that should be very well resolved before starting and budgeting a GMP washer installation project:<\/p>\n<ul>\n<li style=\"text-align: left;\"><strong><b><span lang=\"EN-GB\">Identifying and grouping the parts to be washe:<\/span><\/b><\/strong>\u00a0<span lang=\"EN-GB\">Unlike what is commonly believed, there are very few products that cannot be washed with a GMP washing machine. From critical parts in contact with the product such as format pieces (punches, dies,\u2026), containers (IBCs, drums, mixing containers, \u2026) to production components (valves, housings, hoses, etc.) and accessories (freeze drying trays, carrousels, etc.). \u00a0Parts washing are done by batches or loads with a specific cycle. To ensure proper cleaning of each part, it is necessary to transmit them to the supplier. From here, the most appropriate chamber size is selected, and load racks are designed to adapt to the load. The design of racks is not only for support purposes, they are custom designed using 3D scanning technology<\/span>.<span lang=\"EN-GB\">Thanks to the custom design, the placement of the parts is univocal, ease and intuitive, ensuring proper coverage during washing and full drainability<\/span>.\n<p style=\"text-align: center;\"><img decoding=\"async\" class=\"lazyload aligncenter wp-image-9912 size-full\" src=\"data:image\/svg+xml,%3Csvg%20xmlns%3D%27http%3A%2F%2Fwww.w3.org%2F2000%2Fsvg%27%20width%3D%27642%27%20height%3D%27239%27%20viewBox%3D%270%200%20642%20239%27%3E%3Crect%20width%3D%27642%27%20height%3D%27239%27%20fill-opacity%3D%220%22%2F%3E%3C%2Fsvg%3E\" data-orig-src=\"\/wp-content\/uploads\/2023\/03\/gmp-washing-machine-3d.jpg\" alt=\"3D images of the storage tank and intermediate tank of a GMP washing machine.\" width=\"642\" height=\"239\" \/><\/p>\n<p style=\"text-align: center;\">Rack 1: Dosing pumps, injectors, storage tank and others<\/p>\n<p style=\"text-align: center;\">Rack 2: Valves, connectors, hoses, intermediate tanks and others<\/p>\n<p><span lang=\"EN-GB\">The rack, by itself, is piping system that, by means of quick coupling devices and multiple injection points, injects pressurised jets of water to the internal surfaces of the parts to be washed, cleaning by mechanical, chemical and temperature effect<\/span>.<\/li>\n<li><strong><b><span lang=\"EN-GB\">Degrees and types of residues<\/span><\/b>.<\/strong>\u00a0<span lang=\"EN-GB\">In general, you have a good knowledge of the residues that your products entail since it is already being cleaned manually. Possible contaminants such as residues of active ingredients or excipients, residues of lubricants or detergents, microbial load, etc. may require specific solutions<\/span>.<\/li>\n<li><strong><b><span lang=\"EN-GB\">Location of the equipment<\/span><\/b>.<\/strong>\u00a0Ensure that the dimensions of the equipment and the architecture of the room are compatible. The washing equipment is usually very compact and requires a footprint quite reduced with respect to its load capacity but still has a significant size and the rooms are not always provided for this type of equipment. It is also necessary to consider the services for the operation of the equipment, especially those more critics such as the WFI that may entail a significant additional cost.<\/li>\n<\/ul>\n<h2 class=\"fusion-responsive-typography-calculated\" data-fontsize=\"19\" data-lineheight=\"28.5px\"><span class=\"ez-toc-section\" id=\"Comparative_table_between_manual_vs_automatic_cleaning\"><\/span>Comparative table between manual vs automatic cleaning<span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p><img decoding=\"async\" class=\"lazyload aligncenter wp-image-4798 size-large\" src=\"data:image\/svg+xml,%3Csvg%20xmlns%3D%27http%3A%2F%2Fwww.w3.org%2F2000%2Fsvg%27%20width%3D%271024%27%20height%3D%27494%27%20viewBox%3D%270%200%201024%20494%27%3E%3Crect%20width%3D%271024%27%20height%3D%27494%27%20fill-opacity%3D%220%22%2F%3E%3C%2Fsvg%3E\" data-orig-src=\"\/wp-content\/uploads\/2023\/03\/comparative-table.jpg\" alt=\"Comparative table between Manual vs Automatic cleaning.\" width=\"1024\" height=\"494\" \/><\/p>\n<\/div><\/div><\/div><\/div><\/div>\n\n\n<div class=\"kk-star-ratings kksr-auto kksr-align-left kksr-valign-bottom\"\n    data-payload='{&quot;align&quot;:&quot;left&quot;,&quot;id&quot;:&quot;12278&quot;,&quot;slug&quot;:&quot;default&quot;,&quot;valign&quot;:&quot;bottom&quot;,&quot;ignore&quot;:&quot;&quot;,&quot;reference&quot;:&quot;auto&quot;,&quot;class&quot;:&quot;&quot;,&quot;count&quot;:&quot;1&quot;,&quot;legendonly&quot;:&quot;&quot;,&quot;readonly&quot;:&quot;&quot;,&quot;score&quot;:&quot;5&quot;,&quot;starsonly&quot;:&quot;&quot;,&quot;best&quot;:&quot;5&quot;,&quot;gap&quot;:&quot;5&quot;,&quot;greet&quot;:&quot;post&quot;,&quot;legend&quot;:&quot;5\\\/5 - (1 vote)&quot;,&quot;size&quot;:&quot;24&quot;,&quot;title&quot;:&quot;GMP washing machines: COP equipment&quot;,&quot;width&quot;:&quot;142.5&quot;,&quot;_legend&quot;:&quot;{score}\\\/{best} - ({count} {votes})&quot;,&quot;font_factor&quot;:&quot;1.25&quot;}'>\n            \n<div class=\"kksr-stars\">\n    \n<div class=\"kksr-stars-inactive\">\n            <div class=\"kksr-star\" data-star=\"1\" style=\"padding-right: 5px\">\n            \n\n<div class=\"kksr-icon\" style=\"width: 24px; height: 24px;\"><\/div>\n        <\/div>\n            <div class=\"kksr-star\" data-star=\"2\" style=\"padding-right: 5px\">\n            \n\n<div class=\"kksr-icon\" style=\"width: 24px; height: 24px;\"><\/div>\n        <\/div>\n            <div class=\"kksr-star\" data-star=\"3\" style=\"padding-right: 5px\">\n            \n\n<div class=\"kksr-icon\" style=\"width: 24px; height: 24px;\"><\/div>\n        <\/div>\n            <div class=\"kksr-star\" data-star=\"4\" style=\"padding-right: 5px\">\n            \n\n<div class=\"kksr-icon\" style=\"width: 24px; height: 24px;\"><\/div>\n        <\/div>\n            <div class=\"kksr-star\" data-star=\"5\" style=\"padding-right: 5px\">\n            \n\n<div class=\"kksr-icon\" style=\"width: 24px; height: 24px;\"><\/div>\n        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class=\"kksr-legend\" style=\"font-size: 19.2px;\">\n            5\/5 - (1 vote)    <\/div>\n    <\/div>\n","protected":false},"excerpt":{"rendered":"","protected":false},"author":2,"featured_media":12360,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[],"tags":[],"class_list":["post-12278","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.7 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>GMP washing machines for pharmaceutical production<\/title>\n<meta name=\"description\" content=\"Comprehensive analysis of washing solutions in pharmaceutical production: COP automation equipment, ROI, advantages and project considerations.\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" 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